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Beyond Statins: Emerging Lipid-Lowering Therapies for Atherosclerotic Cardiovascular Disease (ASCVD) (Record no. 133020)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02461nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251013b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alvina Christiana B |
| 245 ## - TITLE STATEMENT | |
| Title | Beyond Statins: Emerging Lipid-Lowering Therapies for Atherosclerotic Cardiovascular Disease (ASCVD) |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp25-34 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Background:<br/>Statins have long been the cornerstone of lipid-lowering therapy for the prevention and management of atherosclerotic<br/>cardiovascular disease (ASCVD). Despite their proven efficacy, a significant proportion of patients remain at high residual<br/>cardiovascular risk due to statin intolerance, inadequate LDL-C lowering, or other lipid-related abnormalities.<br/>Objective:<br/>This review aims to provide an up-to-date overview of emerging lipid-lowering therapies that extend beyond statins, focusing on<br/>their mechanisms of action, clinical efficacy, and integration into contemporary lipid management.<br/>Methods:<br/>We analyzed data from key randomized controlled trials, consensus statements, and recent clinical guidelines to evaluate the<br/>efficacy, safety, and clinical roles of novel therapies including PCSK9 inhibitors, inclisiran, bempedoic acid, ezetimibe, antisense<br/>and siRNA-based agents targeting lipoprotein(a) and ApoC-III, and triglyceride-lowering interventions.<br/>Results:<br/>New agents demonstrate substantial LDL-C and triglyceride reductions, improved patient adherence, and favorable<br/>cardiovascular outcomes in high-risk populations. Therapies targeting lipoprotein(a), ApoC-III, and ANGPTL3 represent<br/>promising tools for future risk reduction. Combination and personalized approaches tailored to individual lipid profiles and<br/>genetic risk factors are now recommended in updated guidelines.<br/>Conclusion:<br/>Emerging lipid-lowering therapies offer significant promise in reducing residual ASCVD risk, particularly when integrated into a<br/>comprehensive, personalized treatment strategy. The evolving therapeutic landscape heralds a shift toward precision lipidology<br/>and underscores the need for broader access and clinician education to optimize patient outcomes.<br/> |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Atherosclerotic Cardiovascular Disease (ASCVD)">Atherosclerotic Cardiovascular Disease (ASCVD)</a> |
| -- | <a href="lipid-lowering therapy">lipid-lowering therapy</a> |
| -- | <a href=" PCSK9 inhibitors"> PCSK9 inhibitors</a> |
| -- | <a href="inclisiran">inclisiran</a> |
| -- | <a href="bempedoic acid">bempedoic acid</a> |
| -- | <a href=" lipoprotein(a), triglycerides"> lipoprotein(a), triglycerides</a> |
| -- | <a href=" ApoC-III inhibition"> ApoC-III inhibition</a> |
| -- | <a href="ANGPTL3">ANGPTL3</a> |
| -- | <a href=" statin intolerance"> statin intolerance</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jona Joy |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125267 |
| Host Itemnumber | 114071 |
| Place, publisher, and date of publication | Rajasthan Health Education Bureau |
| Title | Journal of Hospital Pharmacy |
| International Standard Serial Number | 2348-7704 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 13/10/2025 | jp946.4 | 13/10/2025 | 13/10/2025 | Journal Article |