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ELECTROSPUN NANOFIBER FILMS FOR BUCCAL ADMINISTRATION OF GLIBENCLAMIDE (Record no. 133124)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01971nam a2200157 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251030b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sreehari S. Nair |
| 245 ## - TITLE STATEMENT | |
| Title | ELECTROSPUN NANOFIBER FILMS FOR BUCCAL ADMINISTRATION OF GLIBENCLAMIDE |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Page No. 43-52 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | This study aimed to develop and evaluate glibenclamide-loaded electrospun nanofiber films for buccal delivery, a promising strategy to overcome the solubility and bioavailability challenges associated with this biopharmaceutics classification system class II drug. The nanofiber films were formulated using electrospinning technology, incorporating polymers such as polyvinylpyrrolidone and ethyl cellulose. A central composite design was employed to optimize the formulation, focusing on factors like polymer concentration and flow rate. The optimized nanofiber film exhibited significant drug entrapment efficiency (93.56 %) and a sustained drug release of 90.72 % over 8 h. Scanning electron microscopy confirmed the uniform and non-crystalline nature of the nanofibers, indicating successful encapsulation of glibenclamide in an amorphous state. In vitro and ex vivo studies further demonstrated improved drug permeability through goat buccal mucosa. Mucoadhesive strength was measured at 17.12 g, ensuring prolonged buccal retention, while stability studies under accelerated conditions revealed no significant degradation over three months. The findings suggest that glibenclamide-loaded nanofiber films can enhance drug bioavailability through buccal administration, providing a practical substitute for traditional oral dosage forms for treating type II diabetes mellitus. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="FESEM analysis">FESEM analysis</a> |
| -- | <a href="HRTEM ananlysis">HRTEM ananlysis</a> |
| -- | <a href="muthuchippi parpam">muthuchippi parpam</a> |
| -- | <a href="elemental analysis">elemental analysis</a> |
| -- | <a href="EDS analysis">EDS analysis</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shradha B. Adhalraob |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 114088 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 30/10/2025 | jp954.3 | 30/10/2025 | 30/10/2025 | Journal Article |