Nicodemus Emeka Nwankwo <br/><br/>
Examination of the lipid profile, antioxidant capacity, and impact of Sida linifoliaL.extract on the liver and kidney functions of mice infected with malaria 

 - p.524-534 
<br/><br/> The study aimed to investigate the impact of treatment with the ethanolic leaf extract of Sida linifolia(ELES) in malaria-infected mice and the effect of the extract on tissues and organs. Phytochemical screening was conducted, and the liver and kidney function parameters, lipid profile, antioxidant parameters, and electrolyte status were determined. From the findings of  the  study,  tannins,  saponins,  flavonoids,  steroids,  and  other  phytochemicals  were  detected.  The  activities  of  alkaline phosphatase, aspartate aminotransferase, superoxide dismutase, and total protein, triacylglycerol, high-density lipoproteins, and electrolytes concentrations of the infected animals treated with different doses of the extract were significantly (p <0.05) higher  compared  to  the  untreated  group  (positive  control).  Conversely,  the  levels  of  creatinine,  urea,  total  bilirubin,  total cholesterol,  low-density  lipoproteins,  and  catalase  activity  of  the  treated  groups  were  significantly  (p <0.05)  lower  than those  of  the  positive  control.  The  malondialdehyde  and  reduced  glutathione  concentrations  of  the  treated  group  showeda non-significant (p >0.05) difference compared to the positive control. Overall, these findings suggest that the ethanolic leaf extract of S. linifoliaexerted an antioxidant effect, but some perturbations in the electrolyte concentrations and the elevated levels  of the  liver  enzymes  could  mean  some  potential  stress  to  some  tissues  and  the  liver,  so  care  should be  taken  in  the administration of the agent. 
<br/><br/><label>Subjects--Facted Index Terms: </label><br/>Biomarkers<br/>Kidney function<br/> Liver function<br/>Malaria<br/>Phytochemical<br/> Toxicity