TY  - BOOK
AU  - Chetan Kumar Shettya
AU  -  Sheeba F. Roseleta
TI  - FORMULATION AND CHARACTERIZATION OF PH-INDUCED IONIC GELATION CIMETIDINE ORAL IN SITU GEL FOR TARGETED GASTRIC DELIVERY
KW  - floating in situ gel
KW  - targeted drug delivery
KW  - climetidine
KW  - sodium alginate
KW  - xanthan gum
KW  - gellan gum
N2  - Cimetidine is an orally administered anti-ulcer medication. This study aims to develop a gastro-retentive in situ gel containing the drug to enhance its oral bioavailability and provide prolonged release. The gel was prepared by incorporating an emulsion into a polymeric solution, resulting in a floating in situ gel. The prepared solution was evaluated for pH, viscosity, drug content and in vitro drug release. The in vitro drug release studies demonstrated good drug release, ranging from 61.64% to 84.4% over 10 h. The best formulation, identified as F4, exhibited an in vitro drug release, of 68.64%. The correlation coefficient values from kinetic equations indicated that drug release from the formulations followed a Higuchi first-order release mechanism. The approved formulations met all the criteria for developing a gastro-retentive in situ gel system that gelled quickly and floated within the stomach’s pH range
ER  -