Background:
Oncology units within specialized and high-stress hospital settings create significant emotional and psychological stress in nurses, which can affect their quality of work life (QWL). This study aimed to determine the correlation between QWL and caring nurse-patient interactions with burnout among oncology nurses.

Methods and Materials:
In this correlational study, 200 oncology nurses were selected using convenience sampling. Data collection scales included the valid and reliable Maslach Burnout Inventory, the caring nurse–patient interaction questionnaire, and Brook’s Quality of Nursing Work Life Questionnaire. The collected data were analyzed using SPSS20 software.

Results:
The results showed an inverse and significant linear relationship between QWL and caring nurse-patient interactions with burnout among oncology nurses. In addition, there was a direct and significant linear relationship between QWL and nurse–patient care interactions.

Conclusion:
Considering the significant relationship between QWL and nurse–patient care interactions with a burnout in nurses, it seems that, according to the special mental atmosphere of oncology departments, it is necessary to have a written plan to reduce burnout in nurses.