An open letter to the community of organic chemists / Pavol Kováč -- Alzheimer’s disease, the importance of A[beta] and the hopes for chemo preventatives / Helma Antony and Ian Macreadie ; reviewed by Vidana Epa, Victor Strelsov, and Ross Fernley -- Novel class of antibacterial agents : inhibitors of enoyl-acyl carrier protein reductases FabI and Fabk / Hideo Kitagawa, Tomohiro Ozawa, and Keiichi Ajito -- Progress in the discovery of SERCA inhibitors / Stefan Paula -- G-quadruplex interactive telomerase inhibitors : an exciting field to be explored, with some open challenges on the biological evaluation / Marco Franceschin, Armandodoriano Bianco, and Maria Savino -- Polyenthylenimine in medicinal chemistry / Paola Vicennati, Andrea Masotti, and Giancarlo Ortaggi -- Multifunctional delivery vehicles for biomedical applications : polyenthylenimine as a multipurpose polymer / Andrea Masotti, Paola Vicennati, and Giancarlo Ortaggi ; reviewed by Francesco Pampaloni -- Putative bioactive conformers of small molecules : a concerted approach using NMR spectroscopy and computational chemistry / T. Mavromoustakos ... [et al.] -- The N-terminal part of the ligand-binding domain of the human estrogen receptor [alpha] : a new target for estrogen disruptors / D. Gallo, G. Leclercq, and Y. Jacquot -- Some anticancer targets with peptidomimetics as ligands / Li Su and Wenfang Xu