The aim of this study is to better understand the effect of flexible working arrangements (FWAs) on three academics’ outcomes, which are work pressure, work–life conflict and satisfaction during the ongoing COVID-19 pandemic. A quantitative approach using probability-sampling technique was performed to collect the data. A total of 132 responses were considered in this study. The sample includes academics from Middle East and North Africa region. This research used the method of partial least squares to test the research hypotheses. The findings showed that there are significant effects between flexible working-time arrangements, work pressure, work–life conflict with academics’ satisfaction. Yet, both work pressure and work–life conflict do not have moderator roles on the relationship between FWAs and academics’ satisfaction. The research results could be applied by university human resources’ managers seeking to introduce flexible schedules in the workplace in the context of uncertainty. The study makes a novel contribution to the effect of flexible schedules on the attitude of academics during a health crisis (COVID-19).