| 000 | 02272nam a22001817a 4500 | ||
|---|---|---|---|
| 003 | OSt | ||
| 005 | 20241108111542.0 | ||
| 008 | 241108b |||||||| |||| 00| 0 eng d | ||
| 100 | _aGirish Meravanige1 | ||
| 245 | _aDesign and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing | ||
| 300 | _ap122-130 | ||
| 520 | _aThe topical administration of anti-fungal drugs by Solid Lipid Nanoparticles (SLNs) has enormous potential. This study aimed to develop a topical 5-flucytosine-loaded SLNs gel to improve the efficacy of the well-known anti-fungal drug in the treatment of wound healing. Materials and Methods: In order to create 5-flucytosine SLNs, a five-level, two-factor Central-composite design was used. Stearic acid and Poloxamer 407 concentrations of surfactants were chosen as independent factors, and particle size and %Entrapment Efficiency (%EE) were chosen as dependent variables. The produced 5-Flucytosine-SLNs were examined using SEM analysis, zeta potential, polydispersity index, and particle size measurements. Additionally, Carbopol 934 was used to incorporate the improved 5-Flucytosine-SLN formula into gel. Results: The outcomes demonstrated that 5-Flucytosine-SLNs had colloidal sizes with an essentially spherical shape and no aggregation. 5-Flucytosine-SLNs were discovered to have a particle size of 720.4 nm and an Entrapment Efficiency (EE) of 90.28%. The in vitro release, among other assessment criteria, was evaluated for the improved SLN gels. Conclusion: The study's conclusions imply that the topical gels made with 5-Flucytosine-loaded SLNs must be effective in the management of wound healing. | ||
| 654 |
_a 5-Flucytosine _aSolid lipid nanoparticle _aCentral-composite design _aTopical delivery, _a Optimization. |
||
| 700 |
_aRanjitha B2 _aPrakash Goudanavar2 _aGSN Koteswara Rao3 _aB Nirmala Devi4 _a N. Raghavendra Naveen2, _a Afzal Haq Asif5 _a Sree Harsha Nagaraja6,7 _a Mohammed Monirul Islam8 _aPavan Kumar _aPavagada Sreenivasalu9, _a, Mallikarjun Telsang10 _a, Krishna Swaroop Duddi Sreehari1 |
||
| 773 | 0 |
_0125266 _9109601 _dBanglore Association of Pharmaceutical Tearchers of India _oJP44 _tIndian Journal of Pharmaceutical Education and Research _x0019-5464 |
|
| 942 | _cJA | ||
| 942 | _2ddc | ||
| 999 |
_c130064 _d130064 |
||