000			01834nam a2200181 4500
003			OSt
005			20241108171610.0
008			241108b |||||||| |||| 00| 0 eng d
100			_aOrhan Polat1
245			_aHistopathological and Biochemical Investigation of the Effect of Shepherd's Purse (Capsella bursa-pastoris L.) on Ethanol-Induced Liver Damage
300			_ap198-203
520			_a The aim of the present study was to investigate the hepatoprotective effect of Shepherd's Purse (SP) herbal tea on ethanol (EtOH)-induced liver toxicity. Materials and Methods: Male Wistar rats (n = 32) were divided into 4 experimental groups: control, EtOH (30% EtOH), EtOH+SP (30% EtOH+1 mL/kg SP), and SP (1 mL/kg SP orally). EtOH and SP were administered by orogastric gavage once daily. At the end of the 60-day experimental period, tissue and blood samples were obtained from the rats following necropsy. Results: Histopathologically, degenerative-necrotic changes in the liver of the EtOH group rats were partially reduced in the SP treatment group. Biochemical examinations revealed that SP treatment decreased aspartic transaminase, alanine transaminase, and alkaline phosphatase levels in the SP-treated rats compared to the EtOH group rats. While SP treatment had a positive effect on the triglyceride and HDL levels, it had a negative effect on the LDL and cholesterol levels. Conclusion: Consequently, it was determined that SP tea provides partial protection against EtOH-induced liver toxicity.
654			_a: Shepherd's purse _aEthanol, Histopathology _a, Liver, Rat.
700			_a Turan Yaman2 _a Ahmet Ufuk Kömüroğlu3
773	0		_0125266 _9109601 _dBanglore Association of Pharmaceutical Tearchers of India _oJP44 _tIndian Journal of Pharmaceutical Education and Research _x0019-5464
942			_cJA
942			_2ddc
999			_c130083 _d130083