000			01671nam a2200181 4500
003			OSt
005			20250114121349.0
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100			_aVishakha Likhite
245			_aNANO TITANIUM DIOXIDE AS AN EFFICIENT COMPLEXING AGENT FOR THE SYNTHESIS OF CURCUMIN
300			_aP.29-35
520			_aCurcumin is a natural polyphenol known to exhibit multiple therapeutic effects. Methods for the synthesis of curcumin employ complexing of acetylacetone with boron compounds, which protects the active methylene group. As the reactions are not optimal with boron-based complexes, alternative complexing agents for greater efficiency were explored. Amongst these, titanium dioxide and its nanoparticles offered superior complexing activity. This complex was prepared in situ and was characterized to be titanyl acetylacetonate. The reaction conditions were optimized with different solvents, catalysts, water scavenging agents and temperatures using the OVAT (one variable at a time) approach. We then utilized the statistical design of experiments (DOE) approach to optimize critical parameters that influence the yield and purity of curcumin. The optimized reaction conditions yielded curcumin exceeding 90 %, with a reaction time of 8 h, suggesting that nano TiO2 functions very effectively as a complexing agent.
654			_aCurcumin _atitanyl acetylacetonate _anano titaninum dioxide _aresponse surface methodology
700			_aEsha Attar _a Padma Devarajan
773	0		_0125265 _9111177 _dMumbai Indian Drugs Manufacturer's Association _oJP490 _tIndian Drugs _x0019-462X
942			_cJA
942			_2ddc
999			_c130735 _d130735