000			01666nam a2200181 4500
003			OSt
005			20250114122302.0
008			250114b |||||||| |||| 00| 0 eng d
100			_aSurajit Bhattacharjee
245			_aNEUROPROTECTIVE POTENTIAL OF HESPERIDIN AGAINST BENZO(A)PYRENE-INDUCED CEREBRAL PALSY
300			_aP.36-44
520			_aThis study investigates the link between cigarette smoke, specifically benzo(a)pyrene (BaP), and cerebral palsy, focusing on BaP’s neurotoxicity. It also examines the neuroprotective potential of hesperidin, a citrus-derived compound, by assessing its binding affinity with the β4 subunit of Adapter Protein Complex 4 (AP-4). Molecular docking analyses using Discovery Studio and PyRx were performed with the β4 subunit of AP-4 as the protein and benzo(a)pyrene and hesperidin as ligands. The results showed that hesperidin had a higher binding affinity (-7.2 kcal mol-1) compared to BaP (-6.5 kcal mol-1), establishing multiple interactions, including van der Waals, hydrogen, and pi-alkyl bonds. Key receptor residues for hesperidin binding were identified. These findings highlight hesperidin’s potential neuroprotective role, suggesting it may help to prevent BaP-induced neurotoxicity in cerebral palsy. The study emphasizes the promise of hesperidin, encouraging further in vivo and clinical investigations.
654			_aNeuroprotection _ahesperidin _abenzo(a)pyrene _acerebral palsy _amolecular docking
700			_aShubhadeep Chakraborty
773	0		_0125265 _9111177 _dMumbai Indian Drugs Manufacturer's Association _oJP490 _tIndian Drugs _x0019-462X
942			_cJA
942			_2ddc
999			_c130736 _d130736