000			02222nam a2200169 4500
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100			_aNovel food isolates with striking α-glucosidase inhibitory activity and probiotic potential for an antidiabetic role
245			_aHuei-Rong Guo
300			_ap-1283-1294
520			_aIn the current study, ten lactic acid bacteria (LAB) isolates exhibiting anti-α-glucosidase activity were isolated from fermented food. It is directed at novel supplementary diets to prevent/improve diet-induced carbohydrate metabolism disorders and related chronic diseases. Moreover, to evaluate their safety, functionality, and probiotic potential via in vitro simulated test conditions. From 16s-rRNA sequencing, Pediococcus acidilactici (NKUST 803, 845, 858), Lactobacillus plantarum (NKUST 817, 828, 851), Levilactobacillus brevis (NKUST 816, 855) and Lactobacillus acidophilus (NKUST 803, 863) were identified. The results showed that the isolates possessed anti-pathogenic activity, auto-aggregation ability, hydrophobicity (47.44–96.4%), and gastric acid-resistant activity (79–99.1%), which proved their potential for probiotics in nutraceuticals to render hypoglycemic activity or antidiabetic effects to the host positively. Among tested isolates, L. plantarum 817 and P. acidilactici 858 exhibited maximum α-glucosidase inhibitory (AGI) activity of 35–40%. The heat map clearly showed that L. plantarum 817 exhibited the best AGI activity and probiotic potential, among others. These were studied under various simulated gut conditions and safety tests. However, all isolates possess the potential to be used as probiotics in commercial-scale health applications. Pediococcus sp. possesses notable AGI activity but relatively less colonization potential in the gut hence recommended daily intake for positive health effects.
654			_aα-glucosidase inhibitory activity Probiotic Lactobacillus Hypoglycemic effect Diabetes _aProbiotic _aLactobacillus _aHypoglycemic effect _aDiabetes
773	0		_080310 _9109866 _dGermany Springer _oJP261 _tJournal of Food Science and Technology _x0022-1155
942			_cJA
942			_2ddc
999			_c130887 _d130887