000			01637nam a2200157 4500
008			250214b |||||||| |||| 00| 0 eng d
082			_bP.34-39
100			_aKritika R. Saboo
245			_aFORMULATION AND EVALUATION OF TOPICAL ANTIMICROBIAL EMBELIN NIOSOMAL CREAM
300			_aP.34-39
520			_aEmbelin, isolated from Embelia ribes berries is a major constituent isolated by the Soxhlet process and possesses antimicrobial activity. In this report, we develop and evaluate the topical antimicrobial embelin niosomal cream formulation. Niosomal formulation of embelin was formulated using a thin-film hydration method using Tween™ 60, chloroform and phosphate buffer with a rotary evaporator. This niosomal formulation was incorporated into the cream base, where both oil and water phase ingredients were prepared separately at 70 o C by constant stirring to form w/o (water-in-oil) cream formulation. This niosomal cream was evaluated for particle size, entrapment efficacy, spreadability, centrifugation, viscosity, dye test, homogeneity, in vitro antifungal and antibacterial activity against C. albicans and S. aureus, respectively. The zone of inhibition was calculated and further compared with the market formulations. The study proposed that niosomal formulations delivered sustained and prolonged delivery of drug with increase in bioavailability.
654			_aEmbelin _aniosome _athin-film hydration _aentrapment efficacy _aantimicrobial tests
700			_a Rohit R. Ghadgea
773	0		_0125265 _9109909 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c131124 _d131124