000			01418nam a2200157 4500
008			250214b |||||||| |||| 00| 0 eng d
082			_bP.49-58
100			_aKaran K. Lokhande
245			_aFORMULATION AND EVALUATION OF NANOSTRUCTURED LIPID CARRIERS BASED CAPSULE
300			_aP.49-58
520			_aThe objective of this investigation was to formulate an ideal nanostructured lipid carrier (NLC) for glibenclamide in oral capsules. Employing factorial design, the NLC formulation was achieved through high-pressure homogenization using Design-Expert® software, optimized using a 32 -factor experimental design and response surface analysis. Comprehensive analyses were conducted to characterize NLCs and determine the optimal formulation. Rigorous evaluations, including drug content, in vitro diffusion and stability studies, were performed. Safety assessments, efficacy studies and optimization led to the identification of an optimal NLC formulation with specific lipid and surfactant percentages, resulting in a desirable particle size (nm) and a robust zeta potential indicative of strong physical stability.
654			_aNanostructured lipid carriers _aglibenclamide _alipid nanoparticles _acapsule _adiabetes _afactorial design
700			_aPranali P. Malusare
773	0		_0125265 _9109909 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c131126 _d131126