000			01776nam a2200157 4500
008			250217b |||||||| |||| 00| 0 eng d
082			_bP. 63-69
100			_aPriyanka P. Nigade
245			_aIN VIVO EVALUATION OF CURCUMIN REVEALs BIPHASIC ANGIOGENESis ACTIVITY IN ZEBRAFISH EXPERIMENTAL MODEL
300			_aP. 63-69
520			_aCurcumin, a prominent polyphenol compound present in Curcumin longa L., exhibits diverse pharmacological and biological effects. Its hydrophobic nature and poor bioavailability necessitate its solubilization in an amphiphilic solvent such as dimethyl sulfoxide (DMSO) for research purpose. The present study aims to characterize a DMSO-solubilized curcumin and assess the angiogenesis potential of curcumin in zebrafish and chick chorioallantoic membrane (CAM) assay. Curcumin was characterized using UV-Vis spectrophotometry and the angiogenesis effect was evaluated using CAM and zebrafish embryos. The DMSO-solubilized curcumin’s UV-Vis spectrum revealed hypsochromatic shift in wavelength maximum from 425 to 347 nm, indicating solvent-curcumin interaction. Evaluation of angiogenesis activity in the CAM and zebrafish demonstrated dose-dependent promotion of angiogenesis. Curcumin’s biphasic, dose-dependent angiogenesis feature was validated in CAM and zebrafish models, affirming utility of zebrafish model for angiogenesis efficacy study. The solvent-curcumin interactions, molecular properties, and their therapeutic consequences need further investigation.
654			_aCurcumin _abiphasic activities _azebrafish _aangiogenesis _ahypsochromatic effect
700			_aKetaki V. Gurav
773	0		_0125265 _9109908 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c131154 _d131154