000			01828nam a2200157 4500
008			250218b |||||||| |||| 00| 0 eng d
082			_bP.30-37
100			_aSwati M. Keny
245			_aDESIGN AND OPTIMIZATION OF OCULAR INSERTS FOR PROLONGED DELIVERY OF CIPROFLOXACIN WITH CORTICOSTEROID
300			_aP.30-37
520			_aOcular drug delivery is very challenging and fascinating for pharmaceutical researchers, especially in the treatment of ocular conjunctivitis. The challenges include delivery of the drug to the eye without causing permanent tissue damage while maintaining a stable therapeutic level at the site of action for a prolonged period of time. The present work focuses on the treatment of ocular conjunctivitis by using combined mechanisms of fluroquinolone antibiotics, providing sustained release of drug from ocular inserts, and using corticosteroid for anti-inflammatory effect and providing comfort to the patient. Quinolone antibiotics, anti-inflammatory agents and polymers with excipients were procured from pharmaceutical companies as gift samples. Different combinations of antibiotics and anti-inflammatory agents were prepared by solvent cast method and the dried films were cut into defined size containing drug and evaluated for different parameters and sustained drug release. Based on in vitro, in vivo correlation stability studies, the formulation (antibiotic + anti-inflammatory agent) promising the best once a day sustained release of the drug has been chosen.
654			_aQuinolone antibiotics _aanti-inflammatory agents _aconjunctivitis _aoccuserts _ain vitro release pattern _aphysico-chemical evaluation
700			_a Leena A. Sawaikar
773	0		_0125265 _9109669 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c131167 _d131167