000			01525nam a2200157 4500
008			250220b |||||||| |||| 00| 0 eng d
082			_bP.38-45
100			_aKirti Tomer
245			_aDEVELOPMENT AND EVALUATION OF DOMPERIDONE ORAL FILM USING MIXED SOLVENCY CONCEPT
300			_aP.38-45
520			_aThis study aimed to develop and evaluate oral film of antiemetic drug-using mixed solvency concept. The mixed-solvency concept was used in the solubility enhancement of domperidone, an antiemetic drug that is practically insoluble in water. Different types of solubilizers have been used for solubility improvement of domperidone and poly ethylene glycol, niacinamide, caffeine were found to be effective. Five formulations were prepared by using HPMC E15 a film-forming polymer. The prepared oral films were subjected to evaluation for thickness, pH, drug content, folding endurance, stability and in vitro drug release profile. The % in vitro drug release of the best two formulations F3 and F5 were 90.70% and 96.62 % respectively. From the above study, it was concluded that the solubility of the practically insoluble drug, domperidone could be improved successfully by using different water-soluble solubilizers in different ratios under the mixed-solvency concept.
654			_aOral film _aPEG-Polyethyeneglycol _amixed-solvency _aHPMC E15
700			_aAmit Kumar Jain
773	0		_0125265 _9109669 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c131176 _d131176