000			01583nam a2200157 4500
008			250221b |||||||| |||| 00| 0 eng d
082			_bP.52-58
100			_aPrarthna Lakhera
245			_aPREFORMULATION STUDIES AND PROSPECTIVE VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD OF AMOXICILLIN TRIHYDRATE
300			_aP.52-58
520			_aThe current study was embarked upon to evaluate and assess the physicochemical characteristics of amoxicillin trihydrate. The determination and validation of UV-spectrophotometric for amoxicillin trihydrate was included in the study. The different physical characteristics used in preformulation, including solubility, FTIR, loss on drying, melting point, pH, flow qualities, moisture content and partition coefficient, were carefully evaluated and scrutinized. The proposed methods of analysis for amoxicillin trihydrate provide a simple, accurate, and reliable way of analyzing salivary fluid in a simulated buffer solution (pH 6.8) employing a UV spectrophotometer. The UV spectrophotometric method for amoxicillin trihydrate was developed and validated in salivary fluid simulated at pH 6.8. The intraday and interday RSD values both being less than 2 demonstrated that the method is accurate. The recovery study of drug obtained implies the robustness and durability of the method.
654			_aPreformulation _aamoxycilin trihydrate _aUV spectrophotometer _avalidation
700			_aSonia Narwal
773	0		_0125265 _9109707 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c131184 _d131184