000			01750nam a2200157 4500
008			250221b |||||||| |||| 00| 0 eng d
082			_bP.59-63
100			_aManish Goyani
245			_aPREPARATION AND CHARACTERIZATION OF SOLID DISPERSION USEFUL IN MAKING SUBLINGUAL TABLETS OF PIROXICAM
300			_aP.59-63
520			_aThis study aimed to investigate the usage of solid dispersion (SD) to enhance the dissolution rate of the poorly soluble drug piroxicam for sublingual formulation. Poloxamer grade 407 (Kolliphor® P-407), a commercially available polymer, was chosen, and various solid dispersions with different weight ratios of piroxicam and Poloxamer were prepared using the hot melt method. Compatibility tests using FTIR spectroscopy, DSC, and XRD were conducted to assess any chemical or physical interactions between the drug and polymer. In vitro dissolution tests were performed on the solid dispersions. The results of the FTIR spectroscopy study indicated no chemical interaction between the drug and the polymer. Similarly, the DSC and XRD analyses showed no physical interaction between the drug and the polymer. The maximum cumulative percentage release of the pure drug and the solid dispersion at 15 minutes were 40.90±1.83% and 99.56±3.25%, respectively. Based on these findings, it was concluded that the solid dispersion with a ratio of 2:1 (Drug: Poloxamer-407) showed a noteworthy upsurge in the dissolution rate in comparison to the pure drug.
654			_aPiroxicam _aPoloxamer-407 _aSolid dispersion _aFTIR _aDSC _adissolution enhancement
700			_aMeghraj Suryawanshi
773	0		_0125265 _9109707 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c131185 _d131185