000			01893nam a2200133 4500
008			250228b |||||||| |||| 00| 0 eng d
100			_aAvinash Hanmant Hosmani
245			_aDevelopment and Evaluation of Fenofibrate Surface Solid Dispersion For Improved Solubility And Dissolution Rate
300			_apg.446-452
520			_aObjectives: The current work aimed to prepare and characterize Surface-Solid Dispersion (SSD) of Fenofibrate (FNB) in order to improve its solubility and dissolution. Materials and Methods: SSD of FNB has been prepared using solvent evaporation techniques through the combination of hydrophilic polymers such as Aerosil 200, Avicel PH 101, Sodium Starch Glycolate (SSG), Crospovidone (CP) and Croscarmellose Sodium (CCS). The produced SSDs were tested for saturation solubility, production yield, Fourier-Transform Infrared Spectroscopy (FTIR), Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and in vitro dissolution study. Results: PXRD results demonstrated a conversion of the crystalline FNB to an amorphous state when formulated with the carrier, which improved FNB solubility. A decrease in the endothermic peak with respect to FNB in the DSC thermogram of SSD, confirms the loss of crystallinity. Hydrophilic carriers such as Aerosil 200 and CCS at 1:2 (drug: polymer) ratios were found to increase solubility by 3 fold. Conclusion: As a result, the creation of SSD using hydrophilic polymers (Aerosil 200 and CCS) by solvent evaporation seemed to be a novel method that enhanced FNB solubility and dissolution.
654			_aFNB, _aSurface solid dispersion, _a Solvent evaporation, _a, Solubility, _a Dissolution rate.
773	0		_0125266 _9109790 _dBanglore Association of Pharmaceutical Tearchers of India _tIndian Journal of Pharmaceutical Education and Research _x0019-5464
942			_cJA
999			_c131220 _d131220