| 000 | 01169nam a2200121 4500 | ||
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| 008 | 250228b |||||||| |||| 00| 0 eng d | ||
| 100 | _aT Lakshmi Narayanan, | ||
| 245 | _aBerberine’s Therapeutic Prospects in Parkinson’s Disease: A Spotlight on Cholesterol Regulation for Cognitive Improvement | ||
| 520 | _aCholesterol synthesized in astrocytes of the cerebrum plays a pivotal role in regulating hippocampal neurogenesis and cognitive function. Dysregulation of cholesterol metabolism has emerged as a key contributor to the pathogenesis of Parkinson’s disease. Elevated cholesterol levels in the brain are associated with increased oxidative stress and subsequent neurodegeneration of hippocampal pyramidal neurons, culminating in cognitive impairment. Berberine, an isoquinoline alkaloid has the potential to modulate cholesterol synthesis through HMG-CoA inhibition. | ||
| 654 |
_aParkinson’s Disease, _aCognitive impairment, _a Dopamine _a, Cholesterol, _a Alpha-synuclein, _a Berberine |
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| 773 | 0 |
_0125266 _9111205 _dBanglore Association of Pharmaceutical Tearchers of India _tIndian Journal of Pharmaceutical Education and Research _x0019-5464 |
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| 942 | _cJA | ||
| 999 |
_c131237 _d131237 |
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