000			02142nam a2200133 4500
008			250228b |||||||| |||| 00| 0 eng d
100			_aYogesh Mahadeo Amgaonkar
245			_aBoswellic Acid Loaded Nanoemulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, in vitro, ex vivo, and in vivo Evaluation
300			_apg.546-554
520			_aBackground: Topical delivery of medication is often considered to be the best choice due to benefits such as avoidance of gastric degradation, first pass metabolism along with effortless application and retrieval. In topical delivery, the types of the vehicles and the physicochemical characteristics of drug are the prime variables that control the drug release and the therapeutic efficacy. The main component of Boswellia, Boswellic Acid (BA), is assumed to be accountable for the majority of pharmacologic effects. Nanoemulgel combines the benefits of nano-emulsions and the gels. Materials and Methods: The present work carried out with an objective of formulation of topical nanoemulgel of boswellic acid containing carbopol 934 and liquid paraffin as oil base. Results: The prepared nanoemulgel characterized for the various parameters such as, in vitro, ex vivo permeation and in vivo anti-inflammatory activity. The optimized nanoemulsion consisted of carbopol 934 and surfactant mix ratio (tween 80:Span20::1:1), in 1, 1.5 and 2 % w/w. The in vitro, ex vivo permeation of BA from nanoemulgel were found to be 90±0.33% and 85.5±1.2% at 12 hr respectively. Conclusion: Topical application of BA nanoemulgel formulation significantly reduced the inflammation by reducing the serum IL-6 concentration compared with the arthritic rats. The research findings showed that BA nanoemulgel has the ability to increase penetration through the skin and produce an anti-inflammatory impact.
654			_aBoswellic acid _aNanoemulgel, _a, Anti-inflammatory effect, _aRheumatoid arthritis, _aTopical delivery.
773	0		_0125266 _9109790 _dBanglore Association of Pharmaceutical Tearchers of India _tIndian Journal of Pharmaceutical Education and Research _x0019-5464
942			_cJA
999			_c131240 _d131240