000			01574nam a2200145 4500
008			250513b |||||||| |||| 00| 0 eng d
100			_aPrarthna Lakhera
245			_aA SCAFFOLD OF CENTRAL COMPOSITE DESIGN (CCD) IN QUALITY BY DESIGN (QBD) FABRICATION AND ASSESSMENT OF MUCOADHESIVE AMOXICILLIN MICROSPHERES
300			_ap20-27
520			_a In the present investigation, amoxicillin loaded mucoadhesive microspheres were prepared and characterized. The prepared formulation was optimized using two factorial three level central composite experimental design employing response surface methodology. Drug loading (%), and concentration of HPMC (%) were chosen as independent variables. The response yield and drug release were designated as dependable variable. The characterization of fabricated microspheres was conducted by FTIR, scanning electron microscopy (SEM), entrapment efficiency and particle size analysis. Wash out tests and mucoadhesive test of prepared formulations were also carried out. SEM studies revealed the surface smoothness of fabricated microspheres. Further, in vitro release study of preparations was conducted and the results were best fitted into Higuchi kinetic model. The percentage yield and drug release from optimized batch was found to be 72.08 and 85.53, respectively.
654			_aAmoxicillin trihydrate _aevaluation _amicrospheres _aresponses surface methodology
700			_aMinkal Tuteja
773	0		_0125265 _9112354 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c131679 _d131679