000			02138nam a2200133 4500
008			250625b |||||||| |||| 00| 0 eng d
100			_aSithara M S
245			_aAnti-diabetic activity of Kataka Khadirādi Kasāyam in Wistar albino rats
300			_aP 242-252
520			_aKatakakhadirādi Kaṣāyaṃ is an Ayurvedic herbal preparation used for treating diseases such as diabetes, skin, and urinary tract ailments. The objective of present study was to assess antidiabetic potential of Kataka Khadirādi Kaṣhāyaṃ, in Streptozotocin (STZ) induced diabetic Wistar rats for a period of 90 days. Treatment with Katakakhadirādi Kaṣhāyaṃ demonstrated significant efficacy, reducing blood glucose levels to near normal by the 5th week in diabetic rats, showing a 58% reduction compared to day 1 and a 47% reduction in comparison to the diabetic control group's blood glucose levels. However from 7th week onwards, a marked elevation was observed in blood sugar levels of all diabetic rats. Katakakhadirādi Kaṣāyaṃ treatment resulted in 35% reduction in blood level glucose values when compared to that of diabetic control group in 13th week. Hence it can be inferred that, Kaṣāyaṃ had maintained notable hypoglycemic activity despite insulin resistance. Kaṣāyaṃ treatment shows protective nature on liver tissues by reducing the increased levels of serum ALT, AST and ALP. Also it significantly reduced TG levels with a marked reduction in TC, HDL and LDL values. Histological examination also revealed mild to moderate reduction in degenerative changes of liver and kidney tissues and marked regeneration of islet architecture in pancreatic tissues. Katakakhadirādi Kaṣāyaṃ might be able to control the pancreatic beta-cell damage and has hypoglycemic, hypolipidemic and organ protective potential in STZ -induced diabetic rats. Mechanisms of action during insulin resistance is yet to be explored.
654			_aAnti-Diabetic _aKatakakhadirādi Kaṣhāyaṃ _aStreptozotocin _aWistar rats
773	0		_0125286 _9112630 _dNew Delhi NISCAIR _tIndian Journal of Traditional Knowledge _x0972-5938
942			_cJA
999			_c131874 _d131874