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100 _aPallavi Athavale
245 _aIN VITRO EVALUATION OF THE CYTOTOXICITY AND BIOCOMPATIBILITY OF VIDANGADI KSHARA ON LYMPHOMA CANCER CELLS
300 _app67-75
520 _aThe global leading cause of mortality is cancer, with approximately 10 million cancer-related deaths documented in 2020. Vidangadi kshara (VK), a formulation containing Vidanga, Chitraka, Shunthi, Ghrita, Saindhava and Vacha, is traditionally prescribed for Gulma (lump) and Pleeha vyadhi (spleenomegaly). This research aims to evaluate the potential cytotoxic effects and biocompatibility of Vidangadi kshara against lymphoma cells, while assessing its impact on normal cells.The Vidangadi kshara preparation followed classical methodologies and underwent quality analysis according to standard guidelines before being tested for anticancer properties using the tetrazolium-based MTT assay. In mouse fibroblast L929 cells, VK demonstrated cell viability results comparable to cisplatin. When administered at a dose of 1mg, VK exhibited cytotoxic activity against Daudi and Raji Burkitt lymphoma cells. The percentage of cell viability observed with VK treatment was similar to that achieved with cisplatin treatment.
654 _aVidangadi kshara
_aLymphoma cells
_abiocompatibility
_acytotoxic action
700 _a Veena B. Kupatib
773 0 _0132135
_9113083
_aDhanashri S. Dhavale
_tPHYTOCHEMICAL PROFILING AND GC-MS ANALYSIS OF AQUEOUS METHANOL FRACTION OF SEVYACHANDANADI LEPA
942 _cJA
999 _c132138
_d132138