000			01630nam a2200145 4500
008			250805b |||||||| |||| 00| 0 eng d
100			_aRajanikanta Sahu
245			_aEnhancement of metformin bioavailability by Tinospora cordifolia extracts: Insights into pharmacokinetic interactions
300			_app258-270
520			_aTinospora cordifolia aqua-alcoholic extract (TCE) with metformin (MET) has been shown to be significantly more effective against clinical diabetes-associated disorders. Since there is insufficient clarity behind this, pharmacokinetic interaction was investigated to unravel the mechanism partly. A significant increase in area under the curve (AUC0-∞), half-life (T1/2), and decrease in renal clearance (CLr) of MET was observed in animals dosed with TCE (100 mg/Kg) for 14 days. However, no significant change was observed in the time to reach maximum concentration (Tmax), indicating that TCE selectively affects the CLr of MET. Many TCE’s cationic components/metabolites showed a relatively higher potential affinity for organic cationic transporter 2 (OCT2), which partly justifies the selective pharmacokinetic interaction of MET with TCE. In conclusion, TCE enhances the bioavailability of MET by reducing its renal clearance. This partly explains the basis of TCE as a complementary therapy, which requires further validation.
654			_aHerb-drug interactions _aLC-MS, Metformin _aPharmacokinetic _aTinospora cordifolia _aType 2 diabetes
700			_aMahendra Gaur
773	0		_0125285 _9113116 _dNew Delhi NISCAIR _tIndian Journal of Natural Products and Resources _x0976-0504
942			_cJA
999			_c132360 _d132360