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100			_aHiteshi Sabharwal
245			_aInsights into the antibacterial and anti-inflammatory potential of Marchantia polymorpha L. Authors
300			_app279-290
520			_aMarchantia polymorpha, a liverwort of the Marchantiaceae family, has been used in traditional medicine to treat inflammation, fever, pustules, diuresis and skin-related disorders. However, the scientific evaluation and validation of these traditional practices are needed to improve human health care. Among different solvent extracts employed for the analysis of antioxidant, antibacterial and anti-inflammatory potential of M. polymorpha, methanol extract exhibited the highest ferric reducing antioxidant potential, i.e. 122.35±0.57 (μM FeSO4 E) and antibacterial potential as the growth of both gram-positive (S. aureus, B. subtilis and L monocytogenes) and gram-negative (E. coli, K. pneumoniae and P. mirabilis) bacterial cultures was inhibited. More specifically, methanol extract inhibited pro-inflammatory mediators like nitric oxide (NO) in a dose-dependent manner and inflammatory cytokines, i.e. Tumour necrosis factor (TNF-α) and interleukins IL-6 and IL-1β in LPS-induced RAW 264.7 macrophage cell line. Both LC-MS and GC-MS analysis of methanolic extract revealed the presence of numerous phytochemicals responsible for its antibacterial and anti-inflammatory potential, such as Pentadecanal, 3-β-Hydroxy-5-cholen-24-oicacid, Stigmasterol, Phytol, n-Hexadecanoic acid, Ergosterol, Caryophyllene, some important bis-bibenzyls like Marchantin A, Marchantin M, Riccardin D, Plagiochin E and some flavonoids like Rutin, Kaempferol 3-O-glucosyl-rhamnosyl-glucoside and Luteolin 7-O-diglucuronide etc while FTIR characterisation revealed the presence of functional groups like alkenes, alkynes, alcohols, phenols and aromatic compounds etc. Therefore, this study recommends further exploration and development of M. polymorpha-based products in the pharmaceutical and healthcare industries.
654			_aAntibacterial _aAnti-inflammatory _aGC-MS, LC-MS _aMarchantia polymorpha
700			_aGeeta Shukla
773	0		_0125285 _9113116 _dNew Delhi NISCAIR _tIndian Journal of Natural Products and Resources _x0976-0504
942			_cJA
999			_c132362 _d132362