000			02099nam a2200133 4500
008			250805b |||||||| |||| 00| 0 eng d
100			_aS.U.Kankanamge
245			_aAlternative natural sources for commercialised starches as pharmaceutical excipients; Physicochemical properties and applications
300			_app71-79
520			_aStarch is utilised in manufacturing tablets and capsules as a diluent, binder, and disintegrant, dependent on the formulation requirements. Starch is a prominent pharmaceutical excipient due to its non-toxic, non-irritant characteristics, low cost, ease of modification, availability, and versatility in use. Recent findings report that certain commercial starches have the potential to cause allergies, poor compressibility and poor mechanical qualities, together with high importation costs. Different novel starches have been investigated from sources, especially those of tropical origin, such as tubers (sweet potato and cassava) and cereals (rice and sorghum) for physicochemical properties to explore safe and effective excipients. With the improved properties, modified starches such as pregelatinised and acid-treated starches have been developed physically and chemically as multifunctional excipients such as coating agents, super disintegrants, and controlled-release polymers. Comparing the reviewed data with pharmacopeial specifications, the review highlighted pregelatinised starch and acid-modified millet would be beneficial alternatives to commercial starches with their improved stability, solubility, biocompatibility and cost-effectiveness. Hence, the current review attempts to emphasise the physicochemical properties such as pH, bulk and tapped densities, angle of repose of native and modified starches and their uses as binders, disintegrants and diluents in the pharmaceutical industry.
654			_a Binder _aDisintegrant;Modified starches _aPharmaceutical excipient _aPhysicochemical properties _aPlant starches
773	0		_0125285 _9113121 _dNew Delhi NISCAIR _tIndian Journal of Natural Products and Resources _x0976-0504
942			_cJA
999			_c132381 _d132381