000			02910nam a2200145 4500
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100			_a Irfana M. K
245			_aArticle Details COMPARATIVE ASSESSMENT OF THE BIOACTIVE POTENTIAL OF PIMENTA DIOICA STEM EXTRACTS: ANTIOXIDANT AND ANTI-PROLIFERATIVE PROPERTIES
300			_aPage No. 50-56This research explores the antioxidative effects and anti-proliferative action of Pimenta dioica stem extracts. The ethanolic and aqueous extracts were evaluated for their ability to neutralize DPPH radicals, reduce ferric ions, scavenge hydrogen peroxide and exhibit cytotoxic effects on cancer cell lines. The ethanolic extract showed superior DPPH radical scavenging activity (92.36±0.18% inhibition) compared to the aqueous extract (31.76±0.46%). Additionally, the ethanolic extract demonstrated higher ferric-reducing antioxidant power (90.86±0.10%) than the aqueous extract (82.32±0.15%). While both extracts scavenged hydrogen peroxide, the aqueous extract was more effective (28.15±5.09%). The aqueous extract had superior activity (96.22±0.09%) compared to the ethanolic extract in the reducing power assay. Cytotoxicity was evaluated for both extracts in the L929 cell line, and the anti-proliferative study displayed a concentration-responsive action against the SKOV-3 cell line. These findings indicate that P. dioica extracts have notable antioxidant and enhanced anti-proliferative effects against ovarian cancer cells.
520			_aThis research explores the antioxidative effects and anti-proliferative action of Pimenta dioica stem extracts. The ethanolic and aqueous extracts were evaluated for their ability to neutralize DPPH radicals, reduce ferric ions, scavenge hydrogen peroxide and exhibit cytotoxic effects on cancer cell lines. The ethanolic extract showed superior DPPH radical scavenging activity (92.36±0.18% inhibition) compared to the aqueous extract (31.76±0.46%). Additionally, the ethanolic extract demonstrated higher ferric-reducing antioxidant power (90.86±0.10%) than the aqueous extract (82.32±0.15%). While both extracts scavenged hydrogen peroxide, the aqueous extract was more effective (28.15±5.09%). The aqueous extract had superior activity (96.22±0.09%) compared to the ethanolic extract in the reducing power assay. Cytotoxicity was evaluated for both extracts in the L929 cell line, and the anti-proliferative study displayed a concentration-responsive action against the SKOV-3 cell line. These findings indicate that P. dioica extracts have notable antioxidant and enhanced anti-proliferative effects against ovarian cancer cells.
654			_aPimenta dioica _aanti-proliferative _aantioxidant _acell line _aovarian cancer _acytotoxicity
700			_aJayasheela Da
773	0		_0125265 _9113416 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c132522 _d132522