000			02013nam a2200145 4500
008			250911b |||||||| |||| 00| 0 eng d
100			_aAmir Hossein Lame-Jouybari
245			_aAssociation Between Maternal Prepregnancy and Pregnancy Body Mass Index and Children's Telomere Length: A Systematic Review and Meta-analysis
300			_aPP622–635
520			_aContext Telomeres maintain chromosome stability and mark cellular aging, and their shortening with age compromises genomic stability. Objective The purpose of this study was to conduct a meta-analysis of existing evidence to evaluate the relationship between the maternal pregnancy body mass index (BMI) and children's telomere length (TL). Data Source Web of Science, Scopus, and PubMed databases were systematically searched from their inception to August 27, 2023, for pertinent observational studies. Data Extraction The random-effects meta-analysis was conducted on eligible studies that investigated the linear relationship between exposure and the outcomes of interest, utilizing the reported β-coefficient. Cochran’s Q test and I2 statistics were used to assess heterogeneity. Data Analysis A significant association was observed between maternal pregnancy BMI and children's TL (32 studies, pooled effect size [ES]: −0.04; 95% CI: −0.06 to −0.01; I2 = 47.51%, P < .001) and maternal prepregnancy BMI and children's TL at birth (16 studies; pooled ES: −0.05; 95% CI: −0.08 to −0.02; I2 = 53.49%, P < .001). Conclusion The findings indicate an inverse association between maternal prepregnancy BMI and TL in infants, which is evident within the normal to obese BMI range. This underscores the significance of maternal weight status before pregnancy as a determinant of offspring TL
654			_abirth telomere length _a prepregnancy BMI _amaternal weight _a offspring _ameta-analysis
700			_a Mohammad Salar Fahami
773	0		_025311 _9113491 _d2009 _tNutrition Reviews _x0029-6643
942			_cJA
999			_c132761 _d132761