| 000 | 02223nam a2200145 4500 | ||
|---|---|---|---|
| 008 | 250911b |||||||| |||| 00| 0 eng d | ||
| 100 | _aLia Igel Sodré | ||
| 245 | _aOsteogenic Effects of Bioactive Compounds Found in Fruits on Mesenchymal Stem Cells: A Review | ||
| 300 | _app675–691 | ||
| 520 | _aPhytochemicals, which are bioactive compounds contained in fruits, vegetables, and teas, have a positive effect on human health by having anti-inflammatory, antioxidant, and anticarcinogenic effects. Several studies have highlighted the ability of bioactive compounds to activate key cellular enzymes associated with important signaling pathways related to cell division and proliferation, as well as their role in inflammatory and immunological responses. Some phytochemicals are associated with increased proliferation, differentiation, and expression of markers related to osteogenesis, bone formation, and mineralization by activating various signaling pathways. The objective of this study was to clarify which bioactive compounds present in fruits have osteogenic effects on mesenchymal stem cells and the possible associated mechanisms. A literature search was conducted in the LILACS, MEDLINE, and PubMed databases for pertinent articles published between 2014 and 2024. This review included 34 articles that report the osteogenic effects of various bioactive compounds found in different fruits. All the articles reported that phytochemicals play a role in enhancing the regenerative properties of mesenchymal cells, such as proliferation, osteogenic differentiation, secretion of angiogenic factors, and extracellular matrix formation. This review highlights the potential of these phytochemicals in the prevention and treatment of bone diseases. However, more studies are recommended to identify and quantify the therapeutic dose of phytochemicals, investigate their mechanisms in humans, and ensure their safety and effectiveness for health, particularly for bone health. | ||
| 654 |
_aphytochemicals _a fruit _amesenchymal stem cells _amesenchymal stromal cells _aosteogenesis _a bones |
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| 700 | _aMaria Eduarda Cordebello Gall | ||
| 773 | 0 |
_025311 _9113491 _d2009 _tNutrition Reviews _x0029-6643 |
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| 942 | _cJA | ||
| 999 |
_c132767 _d132767 |
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