| 000 | 01995nam a2200145 4500 | ||
|---|---|---|---|
| 008 | 250911b |||||||| |||| 00| 0 eng d | ||
| 100 | _aPeng Jiao | ||
| 245 | _aNutrigenetic and Epigenetic Mechanisms of Maternal Nutrition–Induced Glucolipid Metabolism Changes in the Offspring | ||
| 300 | _app728–748 | ||
| 520 | _aAbstract Maternal nutrition during pregnancy regulates the offspring’s metabolic homeostasis, including insulin sensitivity and the metabolism of glucose and lipids. The fetus undergoes a crucial period of plasticity in the uterus; metabolic changes in the fetus during pregnancy caused by maternal nutrition not only influence fetal growth and development but also have a long-term or even life-long impact for the offspring. Epigenetic modifications, such as DNA methylation, histone modification, and non-coding RNAs, play important roles in intergenerational and transgenerational effects. In this context, this narrative review comprehensively summarizes and analyzes the molecular mechanisms underlying how maternal nutrition, including a high-fat diet, polyunsaturated fatty acid diet, methyl donor nutrient supplementation, feed restriction, and protein restriction during pregnancy, impacts the genes involved in glucolipid metabolism in the liver, adipose tissue, hypothalamus, muscle, and oocytes of the offspring in terms of the epigenetic modifications. This will provide a foundation for the further exploration of nutrigenetic and epigenetic mechanisms for integrative mother–child nutrition and promotion of the offspring’s health through the regulation of maternal nutrition during pregnancy. Note: This paper is part of the Nutrition Reviews Special Collection on Precision Nutrition. | ||
| 654 |
_amaternal nutrition _aoffspring glucolipid metabolism _a nutrigenetics _aepigenetics _a DNA methylation _a histone modification _anon-coding RNAs |
||
| 700 | _aHuizhen Lu, MD | ||
| 773 | 0 |
_025311 _9113491 _d2009 _tNutrition Reviews _x0029-6643 |
|
| 942 | _cJA | ||
| 999 |
_c132770 _d132770 |
||