000			01875nam a2200145 4500
008			251003b |||||||| |||| 00| 0 eng d
100			_aManisha S. Karpe
245			_aMEBENDAZOLE LOADED NANOSPONGES CAPSULES FOR TREATMENT OF WORM INFECTIONS
300			_app18-27
520			_aMebendazole (MBZ), an anthelmintic, was incorporated into nanosponges to improve its delivery. The nanosponges were prepared using polyvinyl alcohol (PVA) as an emulsifying agent and ethylene cellulose as a polymer, via emulsion solvent diffusion. The formulation was optimized using Central Composite Design (CCD) and evaluated for various physicochemical properties, including production yield, entrapment efficiency, particle size, zeta potential and in vitro release. Analytical techniques like Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry, Field emission scanning electron microscopy (FESEM) and X-ray Diffraction were used for evaluation. The production yield was 91.21 %, and entrapment efficiency was 89.13 %. Characterization confirmed successful encapsulation and nanosponge formation. FESEM showed porous, spherical structures and the zeta potential was +11.2 mV with particle size ranging from 514 nm to 554 nm. The in vitro drug release was 86.66 %, and capsule disintegration and content of active were found to be adequate. Stability studies indicated that the capsules were stable. These results suggest that mebendazole-loaded nanosponges effectively address challenges associated with conventional mebendazole formulations.
654			_aMebendazole [MBZ] _aBCS Class II _aAnthelmintic agent _aemulsion solvent evaporation method _acentral composite design [[CCD] _aNanosponges [NS]
700			_aAmit S. Ghosh
773	0		_0125265 _9114075 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c132970 _d132970