000			01583nam a2200145 4500
008			251003b |||||||| |||| 00| 0 eng d
100			_aShrikant S. Tapadiaa
245			_aLIQUISOLID-BASED PULSATILE SYSTEM OF CARVEDILOL: EFFECT OF LIQUISOLID COMPACT ON ANTIHYPERTENSIVE ACTIVITY AND DRUG RELEASE
300			_aPage No. 27-37
520			_aCurrent work was aimed to use liquisolid compact technology to build a pulsatile system containing carvedilol. Liquisolid compact based core tablets were produced with a Syloid® 244FP coating and a Neusilin US2® carrier. The tablets were press-coated with a barrier layer made of the polymers hydroxypropyl methylcellulose K 15M and ethyl cellulose. The physical characteristics of the liquisolidbased pulsatile formulations produced were investigated using differential scanning calorimetry, X-ray diffraction analysis and infrared spectroscopic techniques. Compared with a commercial formulation, optimized liquisolid core-tablets reduced the blood pressure significantly (P<0.0001). The lag time of the tablets with the optimized composition was 6 h. The carvedilol release was 100.002% within 2h after the lag time. Our findings suggest that carvedilol was effectively delivered in the desired pulsatile release pattern by the liquisolid compact-based compression-coated tablets.
654			_aAnthiypertensive _adissolution _alag time _aliquisolid _apulsatile
700			_aDilesh J. Singhavia
773	0		_0125265 _9114075 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c132971 _d132971