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100			_aLucy Mohapatra
245			_aPreclinical Models of Lung Fibrosis: A Gateway for Clinical Research
300			_app1-11
520			_aLung fibrosis (LF) is a form of a severe respiratory disorder that has a survival period of about three to five years after diagnosis. Lung fibrosis is a group of lung disorders characterized by progressive scarring of alveolar tissues. Many models, such as irradiation, exposure to toxins like bleomycin, silica, and fluorescein isothiocyanate and the expression of particular genes using viral vectors or transgenic systems are utilized to examine this disease. A recent model involving repetitive bleomycin lung injury has also been developed, leading to significant lung fibrosis, specifically hyperplasia of alveolar epithelial cells, and persistent abnormal remodelling even after the removal of the stimulus. This model contributes significantly to the pre-existing animal models for lung fibrosis, allowing for the study of temporal heterogeneity and long-term effects. Various in vitro models such as in vitro 2D tissue culture plastic model along with in vitro 3D hydrogel system model and recently developed humanized model has also been discussed in this review. Each of these reviewed models provides a valuable tool for investigating different aspects of lung fibrosis.
654			_aFibrotic Lung _aBleomycin _aSilica _a Fibroblasts _aIsothiocyanate and In vitro model
700			_aDeepak Mishra
773	0		_0125267 _9114071 _dRajasthan Health Education Bureau _tJournal of Hospital Pharmacy _x2348-7704
942			_cJA
999			_c133017 _d133017