000			01613nam a2200145 4500
008			251016b |||||||| |||| 00| 0 eng d
100			_aMahalaxmi M.
245			_aSUBCHRONIC ORAL TOXICITY STUDY IN WISTAR RATS OF SHILAJITWADI VATI, A HERBOMETALLIC FORMULATION
300			_aPage No. 52-57
520			_ahilajitwadi vati, a traditional herbometallic formulation, is used for treating various ailments. This subchronic toxicity study evaluated its safety during extended oral administration due to the inclusion of heavy metals. In compliance with OECD guideline 408, animals were divided into four groups: three received Shilajitwadi vati at doses of 51.36, 205.44, and 513.6 mg kg-1 for 90 days, while the control group received only the vehicle. All the animals showed no signs of toxicity or mortality throughout the study, with steady weight gain and increased feed and water intake. Urine samples, haematological and biochemical parameters were analyzed on day 91, revealing no significant differences between treated and control groups. All data were analysed by one way ANOVA using GraphPad Prism. Histopathological examination showed no adverse effects on vital organs and no metal accumulation in tissues supporting the safety of Shilajitwadi vati. These findings suggest that Shilajitwadi vati is a safe therapeutic option for prolonged use.
654			_aAyurveda _aHerbometallic _ashilajitwadi vati _asubchronic oral toxicity
700			_a Shubhangi H. Pawa
773	0		_0125265 _9114019 _dMumbai Indian Drugs Manufacturer's Association _tIndian Drugs _x0019-462X
942			_cJA
999			_c133046 _d133046