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Inhibition of Bungarus caeruleus snake venom toxicity by Citrus reticulata methanolic extract and in-silico analysis of possible binding modes (Record no. 130682)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02005nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241218b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Srimathi Raghavan |
| 245 ## - TITLE STATEMENT | |
| Title | Inhibition of Bungarus caeruleus snake venom toxicity by Citrus reticulata methanolic extract and in-silico analysis of possible binding modes |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.67-76 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Snakebite envenomation has been one of the major causes of morbidity and mortality around the world. Though intravenous administration of commercial anti-venom systemically neutralizes the toxicity, adverse effects are commonly seen in the post-treatment period. Plant metabolites and their derivatives have been shown to exhibit a wide range of anti-ophidian properties. In this study, we have investigated the Bungaruscaeruleus venom neutralization potential of Citrusaurantiumand Citrus reticulata Blanco peels in terms of phospholipase and hemolytic inhibition. Methanolic extract of C. reticulata exhibited the highest inhibition (93%) of PLA2 activity. However, the extracts of both these Citrusspecies significantly inhibited the hemolytic activity of the venom (54–82%). Molecular docking indicated the binding of thecitrus metabolites to catalytic site residues (TRP19, GLY30, TYR31, GLY32, and HIS48) of PLA2. In vivostudies using Swiss Albino mice confirmed the neutralising capacity of the citrus peel extract, as reflected by the increase in survival time. Therefore, the study reveals that these metabolites in the methanolic extract of the citrus peel can be used as supplements for the management of snake bites. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href=" Snakebite"> Snakebite</a> |
| -- | <a href="Citrus aurantium">Citrus aurantium</a> |
| -- | <a href=" Citrus reticulata"> Citrus reticulata</a> |
| -- | <a href="Venom">Venom</a> |
| -- | <a href=" Neutralization"> Neutralization</a> |
| -- | <a href=" Bungarus caeruleus"> Bungarus caeruleus</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gurunathan Jayaraman |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125286 |
| Host Itemnumber | 109604 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Traditional Knowledge |
| International Standard Serial Number | 0972-5938 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP47 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 18/12/2024 | JP47.9 | 18/12/2024 | 18/12/2024 | Journal Article |