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FORMULATION AND EVALUATION OF β-SITOSTEROL LOADED NIOSOMES FOR ENHANCED ANTIDIABETIC ACTIVITY: A POTENTIAL ALTERNATIVE IN TYPE 2 DIABETES MANAGEMENT

By: Contributor(s): Description: P.45-51Subject(s): DDC classification:
  • P.45-51
 In: Indian Drugs Mumbai Indian Drugs Manufacturer's AssociationSummary: Niosomes, vesicles formed by non-ionic surfactants, offer advantages in drug delivery by enhancing solubilization and encapsulating both lipophilic and hydrophilic drugs. This study focuses on β-sitosterol-loaded niosomes designed to protect its anti-diabetic properties. Formulated with Span™ 60, Span™ 80 and cholesterol, the niosomes showed high entrapment efficiency (90%) and favorable release kinetics. Stability studies confirmed their robustness in various conditions. In vivo experiments demonstrated significant improvements in body weight and blood glucose levels in diabetic rats. The optimized formulation (NF8) exhibited controlled release and substantial antidiabetic activity, suggesting its potential as an effective treatment for type 2 diabetes mellitus.
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Item type Current library Call number Vol info Status Barcode
Journal Article SNDT Juhu P.45-51 (Browse shelf(Opens below)) Available JP151.4
Periodicals SNDT Juhu Vol 61 No 5 Available JP151

Niosomes, vesicles formed by non-ionic surfactants, offer advantages in drug delivery by enhancing solubilization and encapsulating both lipophilic and hydrophilic drugs. This study focuses on β-sitosterol-loaded niosomes designed to protect its anti-diabetic properties. Formulated with Span™ 60, Span™ 80 and cholesterol, the niosomes showed high entrapment efficiency (90%) and favorable release kinetics. Stability studies confirmed their robustness in various conditions. In vivo experiments demonstrated significant improvements in body weight and blood glucose levels in diabetic rats. The optimized formulation (NF8) exhibited controlled release and substantial antidiabetic activity, suggesting its potential as an effective treatment for type 2 diabetes mellitus.

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